Assay Detail
Binding
CHEMBL898742
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Inhibition of C57BL/6 mouse synaptosomal choline transporter
6
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibition of choline transport by redox-active cholinomimetic bis-catechol reagents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.87 | 5.82 |
| Ki | 2 | 4.33 | 4.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1190 | DECAMETHONIUM | 4.0 | 1 | 5.82 |
| CHEMBL138569 | — | — | 2 | 4.68 |
| CHEMBL136284 | — | — | 2 | 4.14 |
| CHEMBL105608 | HEXAMETHONIUM CHLORIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1190 | DECAMETHONIUM | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL138569 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL138569 | — | Ki | = | 31000.0 | nM | 4.51 |
| CHEMBL136284 | — | Ki | = | 73000.0 | nM | 4.14 |
| CHEMBL136284 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL105608 | HEXAMETHONIUM CHLORIDE | IC50 | = | 130000.0 | nM | - |