Assay Detail
Binding
CHEMBL898800
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ZM-241385 from human adenosine A2B receptor expressed in CHO cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Phenylethyl-substituted pyrimido[2,1-f]purinediones and related compounds: structure-activity relationships as adenosine A(1) and A(2A) receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.21 | 6.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL239233 | — | — | 1 | 6.23 |
| CHEMBL441145 | — | — | 1 | 5.14 |
| CHEMBL239864 | — | — | 1 | 5.00 |
| CHEMBL391718 | — | — | 1 | 5.00 |
| CHEMBL239232 | — | — | 1 | 5.00 |
| CHEMBL239018 | — | — | 1 | 4.87 |
| CHEMBL401028 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL239233 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL441145 | — | Ki | = | 7200.0 | nM | 5.14 |
| CHEMBL239864 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL391718 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL239232 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL239018 | — | Ki | = | 13400.0 | nM | 4.87 |
| CHEMBL401028 | — | Ki | > | 10000.0 | nM | - |