Assay Detail
Binding
CHEMBL898851
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.12 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237336 | — | — | 1 | 5.96 |
| CHEMBL237119 | — | — | 1 | 5.34 |
| CHEMBL237337 | — | — | 1 | 4.07 |
| CHEMBL237547 | — | — | 1 | - |
| CHEMBL437557 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237336 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL237119 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL237337 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL237547 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL437557 | — | IC50 | > | 90000.0 | nM | - |