Assay Detail
Functional
CHEMBL899138
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNF-alpha-induced apoptosis in HeLa cells assessed as cell protection
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P(2) amino acid by 2-aminoaryl acids and other non-natural amino acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.84 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237310 | — | — | 1 | 6.35 |
| CHEMBL237308 | — | — | 1 | 5.77 |
| CHEMBL391494 | — | — | 1 | 5.40 |
| CHEMBL393200 | — | — | 1 | - |
| CHEMBL237088 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237310 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL237308 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL391494 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL393200 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL237088 | — | IC50 | > | 2000.0 | nM | - |