Assay Detail
Functional
CHEMBL899147
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at muscarinic M1 receptor in electrically stimulated New Zealand rabbit vas deferens
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Vas deferens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel oxotremorine-related heterocyclic derivatives: Synthesis and in vitro pharmacology at the muscarinic receptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.85 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL239655 | — | — | 1 | 7.40 |
| CHEMBL74300 | — | — | 1 | 6.40 |
| CHEMBL239436 | — | — | 1 | 6.10 |
| CHEMBL239017 | — | — | 1 | 5.46 |
| CHEMBL240764 | — | — | 1 | 5.37 |
| CHEMBL428916 | — | — | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL239655 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL74300 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL239436 | — | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL239017 | — | EC50 | = | 3467.37 | nM | 5.46 |
| CHEMBL240764 | — | EC50 | = | 4265.8 | nM | 5.37 |
| CHEMBL428916 | — | EC50 | = | 44668.36 | nM | 4.35 |