Assay Detail
Functional
CHEMBL899148
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at muscarinic M2 receptor in electrically stimulated guinea-pig left atrium
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cardiac atrium |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel oxotremorine-related heterocyclic derivatives: Synthesis and in vitro pharmacology at the muscarinic receptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.34 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL239655 | — | — | 1 | 8.18 |
| CHEMBL239436 | — | — | 1 | 7.34 |
| CHEMBL238825 | — | — | 1 | 6.60 |
| CHEMBL239017 | — | — | 1 | 6.29 |
| CHEMBL1482 | BETHANECHOL | 4.0 | 1 | 6.19 |
| CHEMBL239866 | — | — | 1 | 5.96 |
| CHEMBL240763 | — | — | 1 | 5.51 |
| CHEMBL428916 | — | — | 1 | 4.66 |
| CHEMBL240764 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL239655 | — | EC50 | = | 6.607 | nM | 8.18 |
| CHEMBL239436 | — | EC50 | = | 45.71 | nM | 7.34 |
| CHEMBL238825 | — | EC50 | = | 251.19 | nM | 6.60 |
| CHEMBL239017 | — | EC50 | = | 512.86 | nM | 6.29 |
| CHEMBL1482 | BETHANECHOL | EC50 | = | 645.65 | nM | 6.19 |
| CHEMBL239866 | — | EC50 | = | 1096.48 | nM | 5.96 |
| CHEMBL240763 | — | EC50 | = | 3090.3 | nM | 5.51 |
| CHEMBL428916 | — | EC50 | = | 21877.62 | nM | 4.66 |
| CHEMBL240764 | — | EC50 | < | 100000.0 | nM | - |