Assay Detail
Binding
CHEMBL899155
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Binding affinity to muscarinic M2 receptor in electrically stimulated guinea-pig left atrium
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cardiac atrium |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel oxotremorine-related heterocyclic derivatives: Synthesis and in vitro pharmacology at the muscarinic receptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 6.34 | 7.03 |
| pKd | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL239655 | — | — | 1 | 7.03 |
| CHEMBL239436 | — | — | 1 | 6.74 |
| CHEMBL238825 | — | — | 1 | 6.72 |
| CHEMBL239866 | — | — | 1 | 6.22 |
| CHEMBL240763 | — | — | 1 | 5.97 |
| CHEMBL1482 | BETHANECHOL | 4.0 | 1 | 5.37 |
| CHEMBL239017 | — | — | 1 | - |
| CHEMBL428916 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL239655 | — | Kd | = | 93.33 | nM | 7.03 |
| CHEMBL239436 | — | Kd | = | 181.97 | nM | 6.74 |
| CHEMBL238825 | — | Kd | = | 190.55 | nM | 6.72 |
| CHEMBL239866 | — | Kd | = | 602.56 | nM | 6.22 |
| CHEMBL240763 | — | Kd | = | 1071.52 | nM | 5.97 |
| CHEMBL1482 | BETHANECHOL | Kd | = | 4265.8 | nM | 5.37 |
| CHEMBL239017 | — | Kd | = | 275422.87 | nM | - |
| CHEMBL428916 | — | pKd | - | — | - |