Assay Detail

CHEMBL899162

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Functional

Cytotoxicity against human A549 cells assessed as cell viability

ChEMBL ↗

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Target

A549 (CHEMBL392) ↗

Open DB target context

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A549 (CHEMBL392) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target A549

CHEMBL392

Anchored from Assay target.

Protein identity A549

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	A549
Confidence	1 — Organism
Curated By	Autocuration

Target

A549 (CHEMBL392) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Natural triterpenoids from Cecropia lyratiloba are cytotoxic to both sensitive and multidrug resistant leukemia cell lines.

Rocha Gda G, Simões M, Lúcio KA, Oliveira RR, Coelho Kaplan MA, Gattass CR.
Bioorg Med Chem (2007) 15 : 7355 -7360
PubMed 17889544 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	4.02	4.02

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL239075	EUSCAPHIC ACID	—	1	4.02

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL239075	EUSCAPHIC ACID	IC50	=	95580.0	nM	4.02