Assay Detail
Functional
CHEMBL899208
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity assessed as inhibition of IL1 stimulated IL6 production in HFF cells by transrepression assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of dissociated non-steroidal glucocorticoid receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 7.63 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 9.30 |
| CHEMBL236755 | — | — | 1 | 8.40 |
| CHEMBL235063 | — | — | 1 | 7.70 |
| CHEMBL392501 | — | — | 1 | 7.40 |
| CHEMBL392500 | — | — | 1 | 7.16 |
| CHEMBL392499 | — | — | 1 | 6.90 |
| CHEMBL393392 | — | — | 1 | 6.55 |
| CHEMBL263091 | — | — | 1 | - |
| CHEMBL235280 | — | — | 1 | - |
| CHEMBL400609 | — | — | 1 | - |
| CHEMBL235689 | — | — | 1 | - |
| CHEMBL429987 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL236755 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL235063 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL392501 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL392500 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL392499 | — | EC50 | = | 125.0 | nM | 6.90 |
| CHEMBL393392 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL263091 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL235280 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL400609 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL235689 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL429987 | — | EC50 | > | 2000.0 | nM | - |