Assay Detail
Functional
CHEMBL899210
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Antiinflammatory activity assessed as upregulation of aromatase in HFF cells by transactivation assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of dissociated non-steroidal glucocorticoid receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.91 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 8.70 |
| CHEMBL236755 | — | — | 1 | 8.10 |
| CHEMBL235063 | — | — | 1 | 7.52 |
| CHEMBL392499 | — | — | 1 | 6.61 |
| CHEMBL392501 | — | — | 1 | 6.60 |
| CHEMBL392500 | — | — | 1 | 6.58 |
| CHEMBL393392 | — | — | 1 | 6.54 |
| CHEMBL400609 | — | — | 1 | 6.18 |
| CHEMBL235689 | — | — | 1 | 5.32 |
| CHEMBL235280 | — | — | 1 | - |
| CHEMBL263091 | — | — | 1 | - |
| CHEMBL429987 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL236755 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL235063 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL392499 | — | EC50 | = | 245.0 | nM | 6.61 |
| CHEMBL392501 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL392500 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL393392 | — | EC50 | = | 285.0 | nM | 6.54 |
| CHEMBL400609 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL235689 | — | EC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL235280 | — | EC50 | - | — | - | |
| CHEMBL263091 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL429987 | — | EC50 | > | 2000.0 | nM | - |