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Assay Detail

CHEMBL899314

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of rabbit muscle GPa
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Oryctolagus cuniculus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Discovering benzamide derivatives as glycogen phosphorylase inhibitors and their binding site at the enzyme.
Chen L, Li H, Liu J, Zhang L, Liu H, Jiang H.
Bioorg Med Chem (2007) 15 : 6763 -6774
PubMed 17719791 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 4.40 5.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL394709 1 5.57
CHEMBL239692 1 5.05
CHEMBL394757 1 5.01
CHEMBL239481 1 4.51
CHEMBL395611 1 4.45
CHEMBL240551 1 4.38
CHEMBL240927 1 4.34
CHEMBL239217 1 4.24
CHEMBL396395 1 4.15
CHEMBL397805 1 4.12
CHEMBL240926 1 4.11
CHEMBL398042 1 4.04
CHEMBL239479 1 4.02
CHEMBL394708 1 4.02
CHEMBL277157 1 4.01
CHEMBL241178 1 -
CHEMBL239002 1 -
CHEMBL239480 1 -
CHEMBL239216 1 -
CHEMBL395380 1 -
CHEMBL391800 1 -
CHEMBL239049 1 -
CHEMBL240762 1 -
CHEMBL239003 1 -
CHEMBL239218 1 -
CHEMBL239253 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL394709 IC50 = 2680.0 nM 5.57
CHEMBL239692 IC50 = 8950.0 nM 5.05
CHEMBL394757 IC50 = 9870.0 nM 5.01
CHEMBL239481 IC50 = 30900.0 nM 4.51
CHEMBL395611 IC50 = 35800.0 nM 4.45
CHEMBL240551 IC50 = 41800.0 nM 4.38
CHEMBL240927 IC50 = 46100.0 nM 4.34
CHEMBL239217 IC50 = 57600.0 nM 4.24
CHEMBL396395 IC50 = 70100.0 nM 4.15
CHEMBL397805 IC50 = 75900.0 nM 4.12
CHEMBL240926 IC50 = 78500.0 nM 4.11
CHEMBL398042 IC50 = 91100.0 nM 4.04
CHEMBL239479 IC50 = 96100.0 nM 4.02
CHEMBL394708 IC50 = 95300.0 nM 4.02
CHEMBL277157 IC50 = 96900.0 nM 4.01
CHEMBL241178 IC50 = 152800.0 nM -
CHEMBL239002 IC50 - -
CHEMBL239480 IC50 - -
CHEMBL239216 IC50 - -
CHEMBL395380 IC50 - -
CHEMBL391800 IC50 = 107400.0 nM -
CHEMBL239049 IC50 = 165600.0 nM -
CHEMBL240762 IC50 = 337100.0 nM -
CHEMBL239003 IC50 = 269100.0 nM -
CHEMBL239218 IC50 = 425000.0 nM -
CHEMBL239253 IC50 = 214600.0 nM -