Assay Detail
Binding
CHEMBL899341
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Inhibition of H+/K+ ATPase in hog gastric mucosa by competitive binding assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Gastric mucosa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel indanyl-substituted imidazo[1,2-a]pyridines as potent reversible inhibitors of the gastric H+/K+-ATPase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.71 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL392962 | — | — | 1 | 6.90 |
| CHEMBL235145 | — | — | 1 | 6.30 |
| CHEMBL238146 | — | — | 1 | 6.20 |
| CHEMBL235366 | — | — | 1 | 5.70 |
| CHEMBL393605 | — | — | 1 | 5.70 |
| CHEMBL392560 | — | — | 1 | 5.40 |
| CHEMBL238352 | — | — | 1 | 4.80 |
| CHEMBL235146 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL392962 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL235145 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL238146 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL235366 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL393605 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL392560 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL238352 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL235146 | — | IC50 | = | 19952.62 | nM | 4.70 |