Assay Detail
Binding
CHEMBL899346
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Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Pyrrolidine-carboxamides and oxadiazoles as potent hNK1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.71 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL392466 | — | — | 1 | 9.77 |
| CHEMBL391964 | — | — | 1 | 9.68 |
| CHEMBL391615 | — | — | 1 | 9.29 |
| CHEMBL392463 | — | — | 1 | 8.55 |
| CHEMBL391963 | — | — | 2 | 8.35 |
| CHEMBL392465 | — | — | 1 | 8.22 |
| CHEMBL235882 | — | — | 1 | 8.10 |
| CHEMBL392464 | — | — | 1 | 7.70 |
| CHEMBL237796 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL392466 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL391964 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL391615 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL392463 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL391963 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL392465 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL235882 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL392464 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL391963 | — | IC50 | - | — | - | |
| CHEMBL237796 | — | IC50 | - | — | - |