Assay Detail
Binding
CHEMBL899404
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Inhibition of yeast PTP1 after 10 mins
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Tyrosine-protein phosphatase 1 (CHEMBL4452) ↗| Type | SINGLE PROTEIN |
| Organism | Saccharomyces cerevisiae S288c |
Publication
2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.70 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL238138 | — | — | 1 | 5.05 |
| CHEMBL393866 | — | — | 1 | 4.77 |
| CHEMBL237915 | — | — | 1 | 4.77 |
| CHEMBL238137 | — | — | 1 | 4.70 |
| CHEMBL236636 | — | — | 1 | 4.64 |
| CHEMBL236216 | — | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL238138 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL393866 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL237915 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL238137 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL236636 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL236216 | — | IC50 | = | 52000.0 | nM | 4.28 |