Assay Detail
Binding
CHEMBL899962
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Inhibition of aurora A kinase
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Hit generation and exploration: imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.22 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL392525 | — | — | 1 | 7.38 |
| CHEMBL237573 | — | — | 1 | 6.60 |
| CHEMBL395601 | — | — | 1 | 6.31 |
| CHEMBL236694 | — | — | 1 | 6.24 |
| CHEMBL237144 | — | — | 1 | 6.13 |
| CHEMBL412173 | — | — | 1 | 6.06 |
| CHEMBL237369 | — | — | 1 | 5.62 |
| CHEMBL235232 | — | — | 1 | 5.37 |
| CHEMBL237142 | — | — | 1 | 5.36 |
| CHEMBL236938 | — | — | 1 | 5.34 |
| CHEMBL394223 | — | — | 1 | 5.23 |
| CHEMBL235451 | — | — | 1 | 5.18 |
| CHEMBL237145 | — | — | 1 | 5.16 |
| CHEMBL391394 | — | — | 1 | 5.16 |
| CHEMBL394674 | — | — | 1 | 5.05 |
| CHEMBL399390 | — | — | 1 | 5.02 |
| CHEMBL235450 | — | — | 1 | 5.00 |
| CHEMBL355818 | — | — | 1 | 4.90 |
| CHEMBL235452 | — | — | 1 | 4.80 |
| CHEMBL236485 | — | — | 1 | 4.78 |
| CHEMBL237361 | — | — | 1 | 4.75 |
| CHEMBL395839 | — | — | 1 | 4.70 |
| CHEMBL236693 | — | — | 1 | 4.60 |
| CHEMBL236937 | — | — | 1 | 4.54 |
| CHEMBL236691 | — | — | 1 | 4.46 |
| CHEMBL236487 | — | — | 1 | 4.40 |
| CHEMBL236277 | — | — | 1 | 4.12 |
| CHEMBL236279 | — | — | 1 | 4.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL392525 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL237573 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL395601 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL236694 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL237144 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL412173 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL237369 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL235232 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL237142 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL236938 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL394223 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL235451 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL237145 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL391394 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL394674 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL399390 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL235450 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL355818 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL235452 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL236485 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL237361 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL395839 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL236693 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL236937 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL236691 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL236487 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL236277 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL236279 | — | IC50 | = | 98000.0 | nM | 4.01 |