Assay Detail
Binding
CHEMBL900121
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Inhibition of human recombinant HDAC1
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.93 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356066 | DACINOSTAT | 2.0 | 1 | 8.10 |
| CHEMBL235674 | — | — | 1 | 7.70 |
| CHEMBL235413 | — | — | 1 | 7.40 |
| CHEMBL235842 | — | — | 1 | 7.40 |
| CHEMBL235192 | — | — | 1 | 7.30 |
| CHEMBL399388 | — | — | 1 | 7.30 |
| CHEMBL237584 | — | — | 1 | 7.30 |
| CHEMBL235210 | — | — | 1 | 7.30 |
| CHEMBL392747 | — | — | 1 | 7.22 |
| CHEMBL393242 | — | — | 1 | 7.22 |
| CHEMBL235411 | — | — | 1 | 6.52 |
| CHEMBL211625 | — | — | 1 | 6.36 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.27 |
| CHEMBL235191 | TACEDINALINE | 3.0 | 1 | 6.05 |
| CHEMBL236061 | — | — | 1 | 5.70 |
| CHEMBL236060 | — | — | 1 | 5.70 |
| CHEMBL399389 | — | — | 1 | - |
| CHEMBL235194 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356066 | DACINOSTAT | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL235674 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL235413 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL235842 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL235192 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL399388 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL237584 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL235210 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL392747 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL393242 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL235411 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL211625 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL235191 | TACEDINALINE | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL236061 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL236060 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL399389 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL235194 | — | IC50 | > | 10000.0 | nM | - |