Assay Detail
Binding
CHEMBL900125
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Inhibition of HDAC in 293T cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | 293T |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.14 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356066 | DACINOSTAT | 2.0 | 1 | 7.30 |
| CHEMBL235210 | — | — | 1 | 6.82 |
| CHEMBL235842 | — | — | 1 | 6.52 |
| CHEMBL393242 | — | — | 1 | 6.05 |
| CHEMBL236061 | — | — | 1 | 5.52 |
| CHEMBL236060 | — | — | 1 | 5.52 |
| CHEMBL235191 | TACEDINALINE | 3.0 | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356066 | DACINOSTAT | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL235210 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL235842 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL393242 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL236061 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL236060 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL235191 | TACEDINALINE | IC50 | = | 6000.0 | nM | 5.22 |