Assay Detail
Functional
CHEMBL900147
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Cytotoxicity against human MIA PaCa2 cells after 4 hrs by MTT assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.51 | 6.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL393760 | — | — | 1 | 6.59 |
| CHEMBL235325 | — | — | 1 | 6.46 |
| CHEMBL235324 | — | — | 1 | 6.46 |
| CHEMBL393095 | — | — | 1 | 6.45 |
| CHEMBL235326 | — | — | 1 | 6.44 |
| CHEMBL391714 | — | — | 1 | 6.37 |
| CHEMBL237620 | — | — | 1 | 6.34 |
| CHEMBL236820 | — | — | 1 | 6.33 |
| CHEMBL393025 | — | — | 1 | 6.30 |
| CHEMBL236821 | — | — | 1 | 6.30 |
| CHEMBL236819 | — | — | 1 | 6.28 |
| CHEMBL438850 | — | — | 1 | 6.20 |
| CHEMBL357217 | — | — | 1 | 6.20 |
| CHEMBL398015 | — | — | 1 | 6.04 |
| CHEMBL237619 | — | — | 1 | 6.04 |
| CHEMBL94277 | — | — | 1 | 5.86 |
| CHEMBL392757 | — | — | 1 | 5.74 |
| CHEMBL237838 | — | — | 1 | 5.70 |
| CHEMBL237641 | — | — | 1 | 5.61 |
| CHEMBL428382 | — | — | 1 | 5.59 |
| CHEMBL235531 | — | — | 1 | 5.34 |
| CHEMBL113131 | — | — | 1 | 5.33 |
| CHEMBL14205 | NITROPHENOLATE | — | 1 | 5.22 |
| CHEMBL13888 | 3-NITRO-PHENOL | — | 1 | 5.15 |
| CHEMBL395435 | — | — | 1 | 5.02 |
| CHEMBL14130 | P-NITROPHENOL | — | 1 | 4.96 |
| CHEMBL56226 | — | — | 1 | 4.91 |
| CHEMBL539165 | — | — | 1 | 4.88 |
| CHEMBL236536 | — | — | 1 | 4.84 |
| CHEMBL395171 | — | — | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL393760 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL235325 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL235324 | — | IC50 | = | 351.0 | nM | 6.46 |
| CHEMBL393095 | — | IC50 | = | 352.0 | nM | 6.45 |
| CHEMBL235326 | — | IC50 | = | 363.0 | nM | 6.44 |
| CHEMBL391714 | — | IC50 | = | 427.0 | nM | 6.37 |
| CHEMBL237620 | — | IC50 | = | 452.0 | nM | 6.34 |
| CHEMBL236820 | — | IC50 | = | 463.0 | nM | 6.33 |
| CHEMBL393025 | — | IC50 | = | 504.0 | nM | 6.30 |
| CHEMBL236821 | — | IC50 | = | 496.0 | nM | 6.30 |
| CHEMBL236819 | — | IC50 | = | 529.0 | nM | 6.28 |
| CHEMBL438850 | — | IC50 | = | 638.0 | nM | 6.20 |
| CHEMBL357217 | — | IC50 | = | 629.0 | nM | 6.20 |
| CHEMBL398015 | — | IC50 | = | 904.0 | nM | 6.04 |
| CHEMBL237619 | — | IC50 | = | 905.0 | nM | 6.04 |
| CHEMBL94277 | — | IC50 | = | 1385.0 | nM | 5.86 |
| CHEMBL392757 | — | IC50 | = | 1829.0 | nM | 5.74 |
| CHEMBL237838 | — | IC50 | = | 2007.0 | nM | 5.70 |
| CHEMBL237641 | — | IC50 | = | 2475.0 | nM | 5.61 |
| CHEMBL428382 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL235531 | — | IC50 | = | 4563.0 | nM | 5.34 |
| CHEMBL113131 | — | IC50 | = | 4654.0 | nM | 5.33 |
| CHEMBL14205 | NITROPHENOLATE | IC50 | = | 6084.0 | nM | 5.22 |
| CHEMBL13888 | 3-NITRO-PHENOL | IC50 | = | 7126.0 | nM | 5.15 |
| CHEMBL395435 | — | IC50 | = | 9579.0 | nM | 5.02 |
| CHEMBL14130 | P-NITROPHENOL | IC50 | = | 10994.0 | nM | 4.96 |
| CHEMBL56226 | — | IC50 | = | 12385.0 | nM | 4.91 |
| CHEMBL539165 | — | IC50 | = | 13053.0 | nM | 4.88 |
| CHEMBL236536 | — | IC50 | = | 14290.0 | nM | 4.84 |
| CHEMBL395171 | — | IC50 | = | 14758.0 | nM | 4.83 |
| CHEMBL273386 | 2,4-DINITROPHENOL | IC50 | = | 15851.0 | nM | 4.80 |
| CHEMBL14060 | PHENOL | IC50 | = | 16535.0 | nM | 4.78 |
| CHEMBL236138 | — | IC50 | = | 36360.0 | nM | 4.44 |
| CHEMBL1142 | 4-AMINOPHENOL | IC50 | = | 41979.0 | nM | 4.38 |
| CHEMBL237459 | — | IC50 | = | 43203.0 | nM | 4.36 |
| CHEMBL237847 | — | IC50 | = | 56480.0 | nM | 4.25 |
| CHEMBL66381 | 4-CYANOPHENOL | IC50 | = | 56830.0 | nM | 4.25 |
| CHEMBL662 | — | IC50 | = | 68137.0 | nM | 4.17 |