Assay Detail
Functional
CHEMBL900148
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Cytotoxicity against human MIA PaCa2 cells after 72 hrs by MTT assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.64 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL393760 | — | — | 1 | 7.12 |
| CHEMBL391714 | — | — | 1 | 7.07 |
| CHEMBL235325 | — | — | 1 | 6.98 |
| CHEMBL393025 | — | — | 1 | 6.80 |
| CHEMBL235326 | — | — | 1 | 6.75 |
| CHEMBL236820 | — | — | 1 | 6.72 |
| CHEMBL237620 | — | — | 1 | 6.67 |
| CHEMBL235324 | — | — | 1 | 6.59 |
| CHEMBL393095 | — | — | 1 | 6.59 |
| CHEMBL236821 | — | — | 1 | 6.51 |
| CHEMBL438850 | — | — | 1 | 6.45 |
| CHEMBL235531 | — | — | 1 | 6.39 |
| CHEMBL236819 | — | — | 1 | 6.38 |
| CHEMBL237619 | — | — | 1 | 6.31 |
| CHEMBL357217 | — | — | 1 | 6.29 |
| CHEMBL398015 | — | — | 1 | 6.25 |
| CHEMBL94277 | — | — | 1 | 6.02 |
| CHEMBL392757 | — | — | 1 | 5.77 |
| CHEMBL237641 | — | — | 1 | 5.74 |
| CHEMBL237838 | — | — | 1 | 5.66 |
| CHEMBL395435 | — | — | 1 | 5.62 |
| CHEMBL428382 | — | — | 1 | 5.49 |
| CHEMBL113131 | — | — | 1 | 5.45 |
| CHEMBL14130 | P-NITROPHENOL | — | 1 | 4.89 |
| CHEMBL56226 | — | — | 1 | 4.88 |
| CHEMBL13888 | 3-NITRO-PHENOL | — | 1 | 4.86 |
| CHEMBL14205 | NITROPHENOLATE | — | 1 | 4.79 |
| CHEMBL14060 | PHENOL | 4.0 | 1 | 4.79 |
| CHEMBL237459 | — | — | 1 | 4.75 |
| CHEMBL236536 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL393760 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL391714 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL235325 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL393025 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL235326 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL236820 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL237620 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL235324 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL393095 | — | IC50 | = | 258.0 | nM | 6.59 |
| CHEMBL236821 | — | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL438850 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL235531 | — | IC50 | = | 409.0 | nM | 6.39 |
| CHEMBL236819 | — | IC50 | = | 417.0 | nM | 6.38 |
| CHEMBL237619 | — | IC50 | = | 493.0 | nM | 6.31 |
| CHEMBL357217 | — | IC50 | = | 508.0 | nM | 6.29 |
| CHEMBL398015 | — | IC50 | = | 562.0 | nM | 6.25 |
| CHEMBL94277 | — | IC50 | = | 962.0 | nM | 6.02 |
| CHEMBL392757 | — | IC50 | = | 1696.0 | nM | 5.77 |
| CHEMBL237641 | — | IC50 | = | 1824.0 | nM | 5.74 |
| CHEMBL237838 | — | IC50 | = | 2172.0 | nM | 5.66 |
| CHEMBL395435 | — | IC50 | = | 2393.0 | nM | 5.62 |
| CHEMBL428382 | — | IC50 | = | 3271.0 | nM | 5.49 |
| CHEMBL113131 | — | IC50 | = | 3556.0 | nM | 5.45 |
| CHEMBL14130 | P-NITROPHENOL | IC50 | = | 12994.0 | nM | 4.89 |
| CHEMBL56226 | — | IC50 | = | 13164.0 | nM | 4.88 |
| CHEMBL13888 | 3-NITRO-PHENOL | IC50 | = | 13856.0 | nM | 4.86 |
| CHEMBL14205 | NITROPHENOLATE | IC50 | = | 16358.0 | nM | 4.79 |
| CHEMBL14060 | PHENOL | IC50 | = | 16045.0 | nM | 4.79 |
| CHEMBL237459 | — | IC50 | = | 17796.0 | nM | 4.75 |
| CHEMBL236536 | — | IC50 | = | 19198.0 | nM | 4.72 |
| CHEMBL395171 | — | IC50 | = | 20772.0 | nM | 4.68 |
| CHEMBL273386 | 2,4-DINITROPHENOL | IC50 | = | 22101.0 | nM | 4.66 |
| CHEMBL539165 | — | IC50 | = | 32926.0 | nM | 4.48 |
| CHEMBL236138 | — | IC50 | = | 38058.0 | nM | 4.42 |
| CHEMBL1142 | 4-AMINOPHENOL | IC50 | = | 42250.0 | nM | 4.37 |
| CHEMBL662 | — | IC50 | = | 68804.0 | nM | 4.16 |
| CHEMBL237847 | — | IC50 | = | 73100.0 | nM | 4.14 |
| CHEMBL66381 | 4-CYANOPHENOL | IC50 | = | 73339.0 | nM | 4.13 |