Assay Detail
Binding
CHEMBL900175
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Electrophorus electricus Acetylcholinesterase
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.70 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1203985 | — | — | 1 | 9.33 |
| CHEMBL1203986 | — | — | 1 | 8.89 |
| CHEMBL540131 | — | — | 1 | 7.58 |
| CHEMBL1203984 | — | — | 2 | 7.54 |
| CHEMBL1677 | TACRINE HYDROCHLORIDE | 4.0 | 1 | 7.37 |
| CHEMBL540132 | — | — | 1 | 7.32 |
| CHEMBL555247 | — | — | 1 | 7.05 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.52 |
| CHEMBL360055 | GALLAMINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1203985 | — | IC50 | = | 0.467 | nM | 9.33 |
| CHEMBL1203986 | — | IC50 | = | 1.28 | nM | 8.89 |
| CHEMBL540131 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1203984 | — | IC50 | = | 28.9 | nM | 7.54 |
| CHEMBL1677 | TACRINE HYDROCHLORIDE | IC50 | = | 42.3 | nM | 7.37 |
| CHEMBL540132 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL555247 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL95 | TACRINE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL360055 | GALLAMINE | IC50 | = | 3150000.0 | nM | - |
| CHEMBL1203984 | — | IC50 | = | 1070000.0 | nM | - |