Assay Detail
Binding
CHEMBL900184
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Binding affinity to transthyretin at pH 4.4
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 13 | 7.98 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL438498 | — | — | 1 | 9.70 |
| CHEMBL240806 | — | — | 1 | 9.52 |
| CHEMBL240805 | — | — | 1 | 8.24 |
| CHEMBL240804 | — | — | 1 | 7.86 |
| CHEMBL241454 | — | — | 1 | 7.57 |
| CHEMBL240808 | — | — | 1 | 7.57 |
| CHEMBL240165 | — | — | 1 | 7.38 |
| CHEMBL241453 | — | — | 1 | 7.06 |
| CHEMBL394034 | — | — | 1 | 6.92 |
| CHEMBL849 | TRICLOSAN | 4.0 | 1 | - |
| CHEMBL559 | DEXTROTHYROXINE | 4.0 | 1 | - |
| CHEMBL241025 | — | — | 1 | - |
| CHEMBL240807 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL438498 | — | Kd | = | 0.2 | nM | 9.70 |
| CHEMBL240806 | — | Kd | = | 0.3 | nM | 9.52 |
| CHEMBL240805 | — | Kd | = | 5.7 | nM | 8.24 |
| CHEMBL240804 | — | Kd | = | 13.9 | nM | 7.86 |
| CHEMBL241454 | — | Kd | = | 27.0 | nM | 7.57 |
| CHEMBL240808 | — | Kd | = | 27.0 | nM | 7.57 |
| CHEMBL240165 | — | Kd | = | 42.0 | nM | 7.38 |
| CHEMBL241453 | — | Kd | = | 88.0 | nM | 7.06 |
| CHEMBL394034 | — | Kd | = | 120.0 | nM | 6.92 |
| CHEMBL849 | TRICLOSAN | Kd | = | 144000.0 | nM | - |
| CHEMBL559 | DEXTROTHYROXINE | Kd | - | — | - | |
| CHEMBL241025 | — | Kd | - | — | - | |
| CHEMBL240807 | — | Kd | - | — | - |