Assay Detail
Functional
CHEMBL900187
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Inhibition of transthyretin fibril formation at pH 4.4
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.33 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL438498 | — | — | 1 | 6.32 |
| CHEMBL240804 | — | — | 1 | 6.28 |
| CHEMBL240805 | — | — | 1 | 6.07 |
| CHEMBL394034 | — | — | 1 | 5.97 |
| CHEMBL241453 | — | — | 1 | 5.88 |
| CHEMBL240806 | — | — | 1 | 5.87 |
| CHEMBL241025 | — | — | 1 | 5.71 |
| CHEMBL240808 | — | — | 1 | 5.59 |
| CHEMBL240165 | — | — | 1 | 5.51 |
| CHEMBL241454 | — | — | 1 | 5.50 |
| CHEMBL240807 | — | — | 1 | 5.50 |
| CHEMBL559 | DEXTROTHYROXINE | 4.0 | 1 | 5.14 |
| CHEMBL241575 | — | — | 1 | 4.70 |
| CHEMBL241573 | — | — | 1 | 4.70 |
| CHEMBL392872 | — | — | 1 | 4.39 |
| CHEMBL238590 | — | — | 1 | 4.35 |
| CHEMBL849 | TRICLOSAN | 4.0 | 1 | 4.27 |
| CHEMBL392873 | — | — | 1 | 4.26 |
| CHEMBL239010 | — | — | 1 | - |
| CHEMBL241576 | — | — | 1 | - |
| CHEMBL241574 | — | — | 1 | - |
| CHEMBL241362 | — | — | 1 | - |
| CHEMBL238802 | — | — | 1 | - |
| CHEMBL238801 | — | — | 1 | - |
| CHEMBL240949 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL438498 | — | IC50 | = | 475.0 | nM | 6.32 |
| CHEMBL240804 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL240805 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL394034 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL241453 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL240806 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL241025 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL240808 | — | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL240165 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL241454 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL240807 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL559 | DEXTROTHYROXINE | IC50 | = | 7170.0 | nM | 5.14 |
| CHEMBL241575 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL241573 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL392872 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL238590 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL849 | TRICLOSAN | IC50 | = | 53500.0 | nM | 4.27 |
| CHEMBL392873 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL239010 | — | IC50 | - | — | - | |
| CHEMBL241576 | — | IC50 | - | — | - | |
| CHEMBL241574 | — | IC50 | - | — | - | |
| CHEMBL241362 | — | IC50 | - | — | - | |
| CHEMBL238802 | — | IC50 | - | — | - | |
| CHEMBL238801 | — | IC50 | - | — | - | |
| CHEMBL240949 | — | IC50 | - | — | - |