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Assay Detail

CHEMBL900205

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human 5HT2C receptor expressed in CHO cells
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

5-hydroxytryptamine receptor 2C (CHEMBL225)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist.
Cole DC, Stock JR, Lennox WJ, Bernotas RC, Ellingboe JW, Boikess S, Coupet J, Smith DL, Leung L, Zhang GM, Feng X, Kelly MF, Galante R, Huang P, Dawson LA, Marquis K, Rosenzweig-Lipson S, Beyer CE, Schechter LE.
J Med Chem (2007) 50 : 5535 -5538
PubMed 17948978 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 6.91 6.91

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL392760 1 6.91

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL392760 Ki = 124.0 nM 6.91