Assay Detail
Functional
CHEMBL900398
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Inhibition of LPS-induced TNFalpha production in mouse J774A.1 cells
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | J774.A1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Syntheses of immunomodulating androstanes and stigmastanes: comparison of their TNF-alpha inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.20 | 7.75 |
| Activity | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL239020 | — | — | 1 | 7.75 |
| CHEMBL393773 | — | — | 1 | 7.46 |
| CHEMBL239019 | — | — | 1 | 7.42 |
| CHEMBL241590 | — | — | 1 | 7.33 |
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 7.32 |
| CHEMBL239235 | — | — | 1 | 6.96 |
| CHEMBL428733 | — | — | 1 | 6.87 |
| CHEMBL90593 | PRASTERONE | 4.0 | 1 | 6.85 |
| CHEMBL393214 | — | — | 1 | 6.84 |
| CHEMBL429279 | — | — | 1 | - |
| CHEMBL241176 | — | — | 1 | - |
| CHEMBL240969 | — | — | 1 | - |
| CHEMBL241378 | — | — | 1 | - |
| CHEMBL398799 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL239020 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL393773 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL239019 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL241590 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL384467 | DEXAMETHASONE | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL239235 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL428733 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL90593 | PRASTERONE | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL393214 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL429279 | — | Activity | - | — | - | |
| CHEMBL241176 | — | Activity | - | — | - | |
| CHEMBL240969 | — | Activity | - | — | - | |
| CHEMBL241378 | — | Activity | - | — | - | |
| CHEMBL398799 | — | Activity | - | — | - |