Assay Detail
Binding
CHEMBL900414
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Inhibition of integrin alpha4beta1 receptor-mediated human Molt-4 cell adhesion to CS1 peptide
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Highly potent, water soluble benzimidazole antagonist for activated alpha 4 beta 1 integrin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.34 | 10.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL395150 | — | — | 1 | 10.43 |
| CHEMBL241445 | — | — | 1 | 9.52 |
| CHEMBL392650 | — | — | 1 | 7.56 |
| CHEMBL241007 | — | — | 1 | 6.73 |
| CHEMBL409586 | — | — | 1 | 6.47 |
| CHEMBL392649 | — | — | 1 | 6.46 |
| CHEMBL239089 | — | — | 1 | 6.38 |
| CHEMBL410756 | — | — | 1 | 6.35 |
| CHEMBL437937 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL395150 | — | IC50 | = | 0.0372 | nM | 10.43 |
| CHEMBL241445 | — | IC50 | = | 0.305 | nM | 9.52 |
| CHEMBL392650 | — | IC50 | = | 27.5 | nM | 7.56 |
| CHEMBL241007 | — | IC50 | = | 185.6 | nM | 6.73 |
| CHEMBL409586 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL392649 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL239089 | — | IC50 | = | 419.5 | nM | 6.38 |
| CHEMBL410756 | — | IC50 | = | 444.0 | nM | 6.35 |
| CHEMBL437937 | — | IC50 | = | 655.0 | nM | 6.18 |