Assay Detail
Functional
CHEMBL900506
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human kappa opioid receptor by [35S]GTPgammaS binding assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthetic studies of neoclerodane diterpenes from Salvia divinorum: exploration of the 1-position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.20 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365533 | — | — | 1 | 6.55 |
| CHEMBL440765 | U-69593 | — | 1 | 6.48 |
| CHEMBL439569 | 1-ALPHA-MESYLOXYSALVINORIN A | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365533 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL440765 | U-69593 | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL439569 | 1-ALPHA-MESYLOXYSALVINORIN A | EC50 | = | 2700.0 | nM | 5.57 |