Assay Detail
Functional
CHEMBL900508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human kappa opioid receptor assessed as inhibition of Galpha-16-induced calcium flux
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthetic studies of neoclerodane diterpenes from Salvia divinorum: exploration of the 1-position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.68 | 8.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445332 | SALVINORIN A | 1.0 | 1 | 8.91 |
| CHEMBL440765 | U-69593 | — | 1 | 8.65 |
| CHEMBL365533 | — | — | 1 | 8.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445332 | SALVINORIN A | EC50 | = | 1.24 | nM | 8.91 |
| CHEMBL440765 | U-69593 | EC50 | = | 2.25 | nM | 8.65 |
| CHEMBL365533 | — | EC50 | = | 3.34 | nM | 8.48 |