Assay Detail
Binding
CHEMBL900568
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Inhibition of HIV1 reverse transcriptase L100I mutant
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and biological properties of novel 2-aminopyrimidin-4(3H)-ones highly potent against HIV-1 mutant strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 5.44 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396816 | — | — | 1 | 6.75 |
| CHEMBL236161 | — | — | 1 | 6.52 |
| CHEMBL239281 | — | — | 1 | 6.51 |
| CHEMBL238701 | — | — | 1 | 6.05 |
| CHEMBL240386 | — | — | 1 | 6.00 |
| CHEMBL239342 | — | — | 1 | 5.70 |
| CHEMBL239337 | — | — | 1 | 5.60 |
| CHEMBL393696 | — | — | 1 | 5.48 |
| CHEMBL238907 | — | — | 1 | 5.40 |
| CHEMBL239064 | — | — | 1 | 5.30 |
| CHEMBL239120 | — | — | 1 | 5.30 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.05 |
| CHEMBL240770 | — | — | 1 | 5.00 |
| CHEMBL391164 | — | — | 1 | 5.00 |
| CHEMBL239063 | — | — | 1 | 5.00 |
| CHEMBL239338 | — | — | 1 | 5.00 |
| CHEMBL239126 | — | — | 1 | 5.00 |
| CHEMBL239717 | — | — | 1 | 5.00 |
| CHEMBL241666 | — | — | 1 | 5.00 |
| CHEMBL240769 | — | — | 1 | 4.82 |
| CHEMBL394990 | — | — | 1 | 4.75 |
| CHEMBL399016 | — | — | 1 | - |
| CHEMBL239122 | — | — | 1 | - |
| CHEMBL238702 | — | — | 1 | - |
| CHEMBL240147 | — | — | 1 | - |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396816 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL236161 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL239281 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL238701 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL240386 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL239342 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL239337 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL393696 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL238907 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL239064 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL239120 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL57 | NEVIRAPINE | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL240770 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL391164 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL239063 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL239338 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL239126 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL239717 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL241666 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL240769 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL394990 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL399016 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL239122 | — | Ki | - | — | - | |
| CHEMBL238702 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL240147 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL223228 | EFAVIRENZ | Ki | - | — | - |