Assay Detail
Functional
CHEMBL900703
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Cytotoxicity against human PT45 cells after 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PT-45 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
3-substituted 7-phenyl-pyrroloquinolinones show potent cytotoxic activity in human cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.46 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 8.40 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.30 |
| CHEMBL393477 | — | — | 1 | 7.70 |
| CHEMBL236350 | — | — | 1 | 7.52 |
| CHEMBL429086 | — | — | 1 | 7.40 |
| CHEMBL236765 | — | — | 1 | 7.40 |
| CHEMBL392818 | — | — | 1 | 7.30 |
| CHEMBL237175 | — | — | 1 | 7.10 |
| CHEMBL392817 | — | — | 1 | 7.00 |
| CHEMBL237176 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL393477 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL236350 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL429086 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL236765 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL392818 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL237175 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL392817 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL237176 | — | IC50 | = | 300.0 | nM | 6.52 |