Assay Detail
Functional
CHEMBL900949
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Inhibition of ADP-induced platelet aggregation in human platelet rich plasma
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship study on the 6-membered heteroaromatic ring system of diphenylpyrazine-type prostacyclin receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.44 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494 | ILOPROST | 4.0 | 1 | 8.30 |
| CHEMBL435883 | BERAPROST SODIUM | 3.0 | 1 | 7.77 |
| CHEMBL396344 | — | — | 1 | 6.70 |
| CHEMBL393007 | — | — | 1 | 6.70 |
| CHEMBL235371 | — | — | 1 | 6.10 |
| CHEMBL235370 | — | — | 1 | 6.10 |
| CHEMBL235151 | — | — | 1 | 5.96 |
| CHEMBL235153 | — | — | 1 | 5.89 |
| CHEMBL117835 | — | — | 1 | 5.82 |
| CHEMBL235152 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494 | ILOPROST | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL435883 | BERAPROST SODIUM | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL396344 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL393007 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL235371 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL235370 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL235151 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL235153 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL117835 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL235152 | — | IC50 | = | 8600.0 | nM | 5.07 |