Assay Detail
Functional
CHEMBL901023
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.40 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL400812 | — | — | 1 | 9.24 |
| CHEMBL235513 | — | — | 1 | 8.50 |
| CHEMBL235717 | — | — | 1 | 7.93 |
| CHEMBL193141 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL400812 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL235513 | — | IC50 | = | 3.14 | nM | 8.50 |
| CHEMBL235717 | — | IC50 | = | 11.61 | nM | 7.93 |
| CHEMBL193141 | — | IC50 | = | 12.0 | nM | 7.92 |