Assay Detail
Functional
CHEMBL901386
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at GHSR
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Growth hormone secretagogue receptor type 1 (CHEMBL4616) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, in vitro, and in vivo characterization of phenylpiperazines and pyridinylpiperazines as potent and selective antagonists of the melanocortin-4 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.62 | 7.10 |
| Intrinsic activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL393576 | — | — | 2 | 7.10 |
| CHEMBL266647 | — | — | 2 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL393576 | — | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL266647 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL266647 | — | Intrinsic activity | = | 47.0 | % | - |
| CHEMBL393576 | — | Intrinsic activity | = | 107.0 | % | - |