Assay Detail
Functional
CHEMBL901439
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Cytotoxicity against human HT29 cells under hypoxic conditions after 4 hrs
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pharmacokinetic/pharmacodynamic model-guided identification of hypoxia-selective 1,2,4-benzotriazine 1,4-dioxides with antitumor activity: the role of extravascular transport.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 5.39 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL239110 | — | — | 1 | 6.52 |
| CHEMBL239111 | — | — | 1 | 6.40 |
| CHEMBL240810 | — | — | 1 | 6.22 |
| CHEMBL239112 | — | — | 1 | 6.22 |
| CHEMBL240811 | — | — | 1 | 6.16 |
| CHEMBL239326 | — | — | 1 | 6.00 |
| CHEMBL238489 | — | — | 1 | 5.89 |
| CHEMBL391371 | — | — | 1 | 5.82 |
| CHEMBL391370 | — | — | 1 | 5.77 |
| CHEMBL238472 | — | — | 1 | 5.75 |
| CHEMBL239325 | — | — | 1 | 5.72 |
| CHEMBL240991 | — | — | 1 | 5.72 |
| CHEMBL240992 | — | — | 1 | 5.70 |
| CHEMBL239109 | — | — | 1 | 5.66 |
| CHEMBL239312 | — | — | 1 | 5.66 |
| CHEMBL239311 | — | — | 1 | 5.58 |
| CHEMBL239534 | — | — | 1 | 5.57 |
| CHEMBL240994 | — | — | 1 | 5.57 |
| CHEMBL239533 | — | — | 1 | 5.55 |
| CHEMBL239092 | — | — | 1 | 5.47 |
| CHEMBL391825 | — | — | 1 | 5.43 |
| CHEMBL241029 | — | — | 1 | 5.42 |
| CHEMBL393895 | — | — | 1 | 5.41 |
| CHEMBL240363 | — | — | 1 | 5.40 |
| CHEMBL239328 | — | — | 1 | 5.40 |
| CHEMBL241418 | — | — | 1 | 5.37 |
| CHEMBL241201 | — | — | 1 | 5.36 |
| CHEMBL240812 | — | — | 1 | 5.30 |
| CHEMBL50882 | TIRAPAZAMINE | 3.0 | 1 | 5.29 |
| CHEMBL241028 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL239110 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL239111 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL239112 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL240810 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL240811 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL239326 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL238489 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL391371 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL391370 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL238472 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL239325 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL240991 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL240992 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL239109 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL239312 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL239311 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL239534 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL240994 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL239533 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL239092 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL391825 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL241029 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL393895 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL239328 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL240363 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL241418 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL241201 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL240812 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL50882 | TIRAPAZAMINE | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL241028 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL394992 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL240784 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL239492 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL240786 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL53592 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL239532 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL239531 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL238685 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL239519 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL239327 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL238881 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL239309 | — | IC50 | = | 40600.0 | nM | 4.39 |
| CHEMBL392225 | — | IC50 | = | 45100.0 | nM | 4.35 |
| CHEMBL240783 | — | IC50 | = | 61200.0 | nM | 4.21 |
| CHEMBL240785 | — | IC50 | = | 103000.0 | nM | - |