Assay Detail
Functional
CHEMBL901441
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Cytotoxicity against human SiHa cells under hypoxic conditions after 4 hrs
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SiHa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pharmacokinetic/pharmacodynamic model-guided identification of hypoxia-selective 1,2,4-benzotriazine 1,4-dioxides with antitumor activity: the role of extravascular transport.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 5.76 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL240811 | — | — | 1 | 6.70 |
| CHEMBL239111 | — | — | 1 | 6.70 |
| CHEMBL239110 | — | — | 1 | 6.70 |
| CHEMBL240810 | — | — | 1 | 6.70 |
| CHEMBL239326 | — | — | 1 | 6.52 |
| CHEMBL239112 | — | — | 1 | 6.52 |
| CHEMBL238489 | — | — | 1 | 6.30 |
| CHEMBL239534 | — | — | 1 | 6.22 |
| CHEMBL240363 | — | — | 1 | 6.22 |
| CHEMBL240992 | — | — | 1 | 6.10 |
| CHEMBL239311 | — | — | 1 | 6.10 |
| CHEMBL239533 | — | — | 1 | 6.10 |
| CHEMBL239109 | — | — | 1 | 6.05 |
| CHEMBL241201 | — | — | 1 | 6.05 |
| CHEMBL241418 | — | — | 1 | 6.05 |
| CHEMBL393895 | — | — | 1 | 6.00 |
| CHEMBL391371 | — | — | 1 | 6.00 |
| CHEMBL239325 | — | — | 1 | 5.96 |
| CHEMBL391825 | — | — | 1 | 5.96 |
| CHEMBL238472 | — | — | 1 | 5.96 |
| CHEMBL240994 | — | — | 1 | 5.96 |
| CHEMBL240991 | — | — | 1 | 5.96 |
| CHEMBL240812 | — | — | 1 | 5.80 |
| CHEMBL239312 | — | — | 1 | 5.77 |
| CHEMBL391370 | — | — | 1 | 5.70 |
| CHEMBL241029 | — | — | 1 | 5.68 |
| CHEMBL239328 | — | — | 1 | 5.66 |
| CHEMBL239092 | — | — | 1 | 5.64 |
| CHEMBL50882 | TIRAPAZAMINE | 3.0 | 1 | 5.60 |
| CHEMBL394992 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL240811 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL240810 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL239110 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL239111 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL239326 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL239112 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL238489 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL239534 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL240363 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL240992 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL239311 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL239533 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL241201 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL241418 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL239109 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL393895 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL391371 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL239325 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL391825 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL238472 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL240994 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL240991 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL240812 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL239312 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL391370 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL241029 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL239328 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL239092 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL50882 | TIRAPAZAMINE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL394992 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL240786 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL241028 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL240784 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL239531 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL239492 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL238685 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL239519 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL239327 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL239532 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL238881 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL240783 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL392225 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL239309 | — | IC50 | = | 31900.0 | nM | 4.50 |
| CHEMBL240785 | — | IC50 | = | 40900.0 | nM | 4.39 |