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Assay Detail

CHEMBL901501

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiparasitic activity against Leishmania donovani MHOM-ET-67/L82 in amastigotes stage
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania donovani
Confidence 1 — Organism
Curated By Intermediate

Target

Leishmania donovani (CHEMBL367)
Type ORGANISM
Organism Leishmania donovani

Publication

Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives.
Kuettel S, Zambon A, Kaiser M, Brun R, Scapozza L, Perozzo R.
J Med Chem (2007) 50 : 5833 -5839
PubMed 17949068 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.10 6.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL125 MILTEFOSINE 4.0 1 6.58
CHEMBL394241 1 5.64
CHEMBL394652 1 5.34
CHEMBL241638 1 5.32
CHEMBL238433 1 5.28
CHEMBL396680 1 5.24
CHEMBL241427 1 5.19
CHEMBL241634 1 5.10
CHEMBL241633 1 5.01
CHEMBL238432 1 5.01
CHEMBL238441 1 4.98
CHEMBL241637 1 4.90
CHEMBL241426 1 4.82
CHEMBL394474 1 4.81
CHEMBL241632 1 4.70
CHEMBL238438 1 4.69
CHEMBL241431 1 4.65
CHEMBL238442 1 4.59

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL125 MILTEFOSINE IC50 = 260.0 nM 6.58
CHEMBL394241 IC50 = 2300.0 nM 5.64
CHEMBL394652 IC50 = 4600.0 nM 5.34
CHEMBL241638 IC50 = 4800.0 nM 5.32
CHEMBL238433 IC50 = 5200.0 nM 5.28
CHEMBL396680 IC50 = 5700.0 nM 5.24
CHEMBL241427 IC50 = 6400.0 nM 5.19
CHEMBL241634 IC50 = 8000.0 nM 5.10
CHEMBL241633 IC50 = 9700.0 nM 5.01
CHEMBL238432 IC50 = 9800.0 nM 5.01
CHEMBL238441 IC50 = 10500.0 nM 4.98
CHEMBL241637 IC50 = 12700.0 nM 4.90
CHEMBL241426 IC50 = 15100.0 nM 4.82
CHEMBL394474 IC50 = 15600.0 nM 4.81
CHEMBL241632 IC50 = 20200.0 nM 4.70
CHEMBL238438 IC50 = 20300.0 nM 4.69
CHEMBL241431 IC50 = 22300.0 nM 4.65
CHEMBL238442 IC50 = 25800.0 nM 4.59