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Assay Detail

CHEMBL901502

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiparasitic activity against chloroquine, pyrimethamine-resistant Plasmodium falciparum K1 erythrocyte stage infected rat L6 cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Cell Type L6
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives.
Kuettel S, Zambon A, Kaiser M, Brun R, Scapozza L, Perozzo R.
J Med Chem (2007) 50 : 5833 -5839
PubMed 17949068 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.42 6.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL76 CHLOROQUINE 4.0 1 6.64
CHEMBL241638 1 5.43
CHEMBL238441 1 5.19
CHEMBL238442 1 5.18
CHEMBL394241 1 5.09
CHEMBL241637 1 4.98
CHEMBL238432 1 -
CHEMBL394652 1 -
CHEMBL238433 1 -
CHEMBL241426 1 -
CHEMBL241427 1 -
CHEMBL394474 1 -
CHEMBL241632 1 -
CHEMBL241633 1 -
CHEMBL396680 1 -
CHEMBL241634 1 -
CHEMBL241431 1 -
CHEMBL238438 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL76 CHLOROQUINE IC50 = 230.0 nM 6.64
CHEMBL241638 IC50 = 3700.0 nM 5.43
CHEMBL238441 IC50 = 6500.0 nM 5.19
CHEMBL238442 IC50 = 6600.0 nM 5.18
CHEMBL394241 IC50 = 8100.0 nM 5.09
CHEMBL241637 IC50 = 10500.0 nM 4.98
CHEMBL238432 IC50 > 19000.0 nM -
CHEMBL394652 IC50 > 15000.0 nM -
CHEMBL238433 IC50 > 15000.0 nM -
CHEMBL241426 IC50 > 19000.0 nM -
CHEMBL241427 IC50 > 15000.0 nM -
CHEMBL394474 IC50 > 14000.0 nM -
CHEMBL241632 IC50 > 18000.0 nM -
CHEMBL241633 IC50 > 15000.0 nM -
CHEMBL396680 IC50 > 13000.0 nM -
CHEMBL241634 IC50 > 15000.0 nM -
CHEMBL241431 IC50 > 13000.0 nM -
CHEMBL238438 IC50 > 14000.0 nM -