Assay Detail
Binding
CHEMBL901569
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Inhibition of MMP8
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Novel fluorinated derivatives of the broad-spectrum MMP inhibitors N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](benzyl)- and (3-picolyl)-amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.73 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235095 | — | — | 1 | 9.05 |
| CHEMBL514138 | CGS-27023A | — | 1 | 8.70 |
| CHEMBL429800 | — | — | 1 | 8.70 |
| CHEMBL392571 | — | — | 1 | 8.70 |
| CHEMBL392308 | — | — | 1 | 8.52 |
| CHEMBL393828 | — | — | 1 | 7.92 |
| CHEMBL236974 | — | — | 1 | 7.85 |
| CHEMBL236770 | — | — | 1 | 7.75 |
| CHEMBL398405 | — | — | 1 | 7.70 |
| CHEMBL392572 | — | — | 1 | 7.12 |
| CHEMBL235916 | — | — | 1 | 6.98 |
| CHEMBL237384 | — | — | 1 | 6.64 |
| CHEMBL393829 | — | — | 1 | 6.12 |
| CHEMBL392088 | — | — | 1 | 5.92 |
| CHEMBL237177 | — | — | 1 | 5.61 |
| CHEMBL398602 | — | — | 1 | 5.17 |
| CHEMBL392974 | — | — | 1 | 5.13 |
| CHEMBL236130 | — | — | 1 | 4.85 |
| CHEMBL235318 | — | — | 1 | 4.66 |
| CHEMBL393793 | — | — | 1 | 4.15 |
| CHEMBL428554 | — | — | 1 | 4.11 |
| CHEMBL236565 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235095 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL429800 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL392571 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL392308 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL393828 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL236974 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL236770 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL398405 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL392572 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL235916 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL237384 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL393829 | — | IC50 | = | 754.0 | nM | 6.12 |
| CHEMBL392088 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL237177 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL398602 | — | IC50 | = | 6760.0 | nM | 5.17 |
| CHEMBL392974 | — | IC50 | = | 7480.0 | nM | 5.13 |
| CHEMBL236130 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL235318 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL393793 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL428554 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL236565 | — | IC50 | - | — | - |