Assay Detail
Functional
CHEMBL901575
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Growth inhibition of MCF7 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.68 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 9.12 |
| CHEMBL235082 | — | — | 1 | 8.29 |
| CHEMBL393360 | — | — | 1 | 7.43 |
| CHEMBL235300 | — | — | 1 | 7.26 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.30 |
| CHEMBL393361 | — | — | 1 | - |
| CHEMBL238036 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343448 | ROMIDEPSIN | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL235082 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL393360 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL235300 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL393361 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL238036 | — | IC50 | > | 1000.0 | nM | - |