Assay Detail
Binding
CHEMBL901576
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Inhibition of HDAC in HeLa nuclear extract in presence of DTT
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.52 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL393361 | — | — | 1 | 8.15 |
| CHEMBL235082 | — | — | 1 | 8.14 |
| CHEMBL393360 | — | — | 1 | 7.82 |
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 7.82 |
| CHEMBL235300 | — | — | 1 | 6.62 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.54 |
| CHEMBL238036 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL393361 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL235082 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL393360 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL343448 | ROMIDEPSIN | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL235300 | — | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL238036 | — | IC50 | > | 3200.0 | nM | - |