Assay Detail
Binding
CHEMBL901577
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Inhibition of HDAC1 in presence of DTT
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.97 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235082 | — | — | 1 | 8.80 |
| CHEMBL393360 | — | — | 1 | 8.80 |
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 8.40 |
| CHEMBL393361 | — | — | 1 | 7.76 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.11 |
| CHEMBL235300 | — | — | 1 | - |
| CHEMBL238036 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235082 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL393360 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL343448 | ROMIDEPSIN | IC50 | = | 3.97 | nM | 8.40 |
| CHEMBL393361 | — | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 775.0 | nM | 6.11 |
| CHEMBL235300 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL238036 | — | IC50 | - | — | - |