Assay Detail
Binding
CHEMBL901578
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Inhibition of HDAC6 in presence of DTT
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.04 | 6.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.71 |
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 6.10 |
| CHEMBL235082 | — | — | 1 | 6.05 |
| CHEMBL393360 | — | — | 1 | 6.05 |
| CHEMBL393361 | — | — | 1 | 5.31 |
| CHEMBL235300 | — | — | 1 | - |
| CHEMBL238036 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL343448 | ROMIDEPSIN | IC50 | = | 787.0 | nM | 6.10 |
| CHEMBL235082 | — | IC50 | = | 897.0 | nM | 6.05 |
| CHEMBL393360 | — | IC50 | = | 881.0 | nM | 6.05 |
| CHEMBL393361 | — | IC50 | = | 4922.0 | nM | 5.31 |
| CHEMBL235300 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL238036 | — | IC50 | - | — | - |