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Assay Detail

CHEMBL901586

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of biotinylated TN14003 from CXCR4 in MDA-MB-231 cells
ChEMBL ↗
61
Total Activities
45
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type MDA-MB-231
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

C-X-C chemokine receptor type 4 (CHEMBL2107) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of small molecule CXCR4 antagonists.
Zhan W, Liang Z, Zhu A, Kurtkaya S, Shim H, Snyder JP, Liotta DC.
J Med Chem (2007) 50 : 5655 -5664
PubMed 17958344 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC 44 - -
EC50 17 9.52 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL237830 — — 2 9.52
CHEMBL237245 — — 1 -
CHEMBL3216204 — — 1 -
CHEMBL3216004 — — 1 -
CHEMBL534939 — — 1 -
CHEMBL536301 — — 1 -
CHEMBL536302 — — 1 -
CHEMBL541646 — — 1 -
CHEMBL3216003 — — 1 -
CHEMBL235309 — — 1 -
CHEMBL235311 — — 1 -
CHEMBL235312 — — 2 -
CHEMBL237190 — — 1 -
CHEMBL396667 — — 2 -
CHEMBL237415 — — 2 -
CHEMBL237418 — — 1 -
CHEMBL391151 — — 2 -
CHEMBL237440 — — 1 -
CHEMBL237628 — — 2 -
CHEMBL392423 — — 2 -
CHEMBL237629 — — 2 -
CHEMBL237631 — — 2 -
CHEMBL235310 — — 2 -
CHEMBL398014 — — 1 -
CHEMBL237439 — — 2 -
CHEMBL237829 — — 2 -
CHEMBL235100 — — 1 -
CHEMBL237223 N-BENZYLANILINE — 1 -
CHEMBL237244 — — 1 -
CHEMBL391658 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL237830 — EC50 = 0.3 nM 9.52
CHEMBL3216204 — EC > 1000.0 nM -
CHEMBL392423 — EC50 = 1000000000.0 nM -
CHEMBL237629 — EC50 = 1000000000.0 nM -
CHEMBL237630 — EC50 = 1000000.0 nM -
CHEMBL237631 — EC50 = 1000000000.0 nM -
CHEMBL237829 — EC50 = 100000000.0 nM -
CHEMBL393855 — EC > 1000.0 nM -
CHEMBL541646 — EC > 1000.0 nM -
CHEMBL536302 — EC > 1000.0 nM -
CHEMBL536301 — EC > 1000.0 nM -
CHEMBL534939 — EC = 100.0 nM -
CHEMBL3216004 — EC > 1000.0 nM -
CHEMBL237628 — EC = 100.0 nM -
CHEMBL235068 — EC = 10.0 nM -
CHEMBL539114 — EC > 1000.0 nM -
CHEMBL538588 — EC > 1000.0 nM -
CHEMBL237164 — EC > 1000.0 nM -
CHEMBL3216003 — EC > 1000.0 nM -
CHEMBL235282 — EC > 1000.0 nM -
CHEMBL397293 TEREPHTHALAMIDE EC > 1000.0 nM -
CHEMBL218733 — EC > 1000.0 nM -
CHEMBL534507 — EC > 1000.0 nM -
CHEMBL3217098 — EC > 1000.0 nM -
CHEMBL235902 — EC > 1000.0 nM -
CHEMBL237630 — EC = 1000.0 nM -
CHEMBL235312 — EC = 200.0 nM -
CHEMBL237164 — EC50 = 1000000.0 nM -
CHEMBL237629 — EC = 1.0 nM -
CHEMBL392423 — EC = 1.0 nM -
CHEMBL237628 — EC50 = 10000000.0 nM -
CHEMBL237440 — EC = 20.0 nM -
CHEMBL391151 — EC = 25.0 nM -
CHEMBL237245 — EC = 80.0 nM -
CHEMBL237418 — EC = 100.0 nM -
CHEMBL237415 — EC = 200.0 nM -
CHEMBL396667 — EC = 50.0 nM -
CHEMBL237190 — EC = 100.0 nM -
CHEMBL237439 — EC50 = 100000000.0 nM -
CHEMBL235311 — EC = 100.0 nM -
CHEMBL235309 — EC = 100.0 nM -
CHEMBL237830 — EC50 = 1000000000.0 nM -
CHEMBL237631 — EC = 1.0 nM -
CHEMBL235310 — EC50 = 100000000.0 nM -
CHEMBL235312 — EC50 = 5011872.34 nM -
CHEMBL396667 — EC50 = 19952623.15 nM -
CHEMBL237415 — EC50 = 5011872.34 nM -
CHEMBL237437 — EC50 = 1000000.0 nM -
CHEMBL237438 — EC50 = 1000000.0 nM -
CHEMBL391151 — EC50 = 39810717.06 nM -