Assay Detail

CHEMBL901589

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Functional

Inhibition of SDF1-mediated invasion of human MDA-MB-231 cells

ChEMBL ↗

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Target

MDA-MB-231 (CHEMBL400) ↗

Open DB target context

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MDA-MB-231 (CHEMBL400) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target MDA-MB-231

CHEMBL400

Anchored from Assay target.

Protein identity MDA-MB-231

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MDA-MB-231
Confidence	1 — Organism
Curated By	Autocuration

Target

MDA-MB-231 (CHEMBL400) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Discovery of small molecule CXCR4 antagonists.

Zhan W, Liang Z, Zhu A, Kurtkaya S, Shim H, Snyder JP, Liotta DC.
J Med Chem (2007) 50 : 5655 -5664
PubMed 17958344 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	8.28	8.28

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL237830	—	—	1	8.28

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL237830	—	EC50	=	5.2	nM	8.28