Assay Detail
Binding
CHEMBL901634
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 1-alpha,25-dihydroxyvitamin from rat recombinant VDR
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological evaluation of a 1alpha,25-dihydroxy-19-norvitamin D3 analogue with a frozen A-ring conformation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.61 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 10.30 |
| CHEMBL392983 | — | — | 1 | 7.52 |
| CHEMBL239096 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL846 | CALCITRIOL | EC50 | = | 0.05 | nM | 10.30 |
| CHEMBL392983 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL239096 | — | EC50 | = | 10000.0 | nM | 5.00 |