Assay Detail
Binding
CHEMBL901651
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Inhibition of Plasmodium falciparum recombinant M17 LAP
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.35 | 7.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL393950 | — | — | 1 | 7.98 |
| CHEMBL393949 | — | — | 1 | 7.88 |
| CHEMBL538595 | BESTATIN HYDROCHLORIDE | — | 1 | 7.60 |
| CHEMBL238227 | — | — | 1 | 7.01 |
| CHEMBL395125 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL393950 | — | Ki | = | 10.4 | nM | 7.98 |
| CHEMBL393949 | — | Ki | = | 13.2 | nM | 7.88 |
| CHEMBL538595 | BESTATIN HYDROCHLORIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL238227 | — | Ki | = | 97.3 | nM | 7.01 |
| CHEMBL395125 | — | Ki | = | 524.8 | nM | 6.28 |