Assay Detail
Functional
CHEMBL901744
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Antiproliferative activity against human SK-N-MC cells by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: structure-activity relationships of novel thiohydrazone analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.01 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385064 | — | — | 1 | 8.70 |
| CHEMBL239762 | — | — | 1 | 7.96 |
| CHEMBL239972 | — | — | 1 | 7.92 |
| CHEMBL231616 | TRIAPINE | 3.0 | 1 | 6.27 |
| CHEMBL390195 | — | — | 1 | 6.23 |
| CHEMBL392652 | — | — | 1 | 6.00 |
| CHEMBL239970 | — | — | 1 | 5.91 |
| CHEMBL239760 | — | — | 1 | 5.83 |
| CHEMBL395362 | — | — | 1 | 5.60 |
| CHEMBL373277 | SALICYLALDEHYDE BENZOYL HYDRAZONE | — | 1 | 5.49 |
| CHEMBL556 | DEFEROXAMINE | 4.0 | 1 | 4.85 |
| CHEMBL392651 | SALICYLALDEHYDE THIOBENZOYL HYDRAZONE | — | 1 | 4.61 |
| CHEMBL428734 | PYRIDOXAL BENZOYL HYDRAZONE | — | 1 | 4.50 |
| CHEMBL238480 | PYRIDOXAL THIOBENZOYL HYDRAZONE | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385064 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL239762 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL239972 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL231616 | TRIAPINE | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL390195 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL392652 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL239970 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL239760 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL395362 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL373277 | SALICYLALDEHYDE BENZOYL HYDRAZONE | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL556 | DEFEROXAMINE | IC50 | = | 14220.0 | nM | 4.85 |
| CHEMBL392651 | SALICYLALDEHYDE THIOBENZOYL HYDRAZONE | IC50 | = | 24470.0 | nM | 4.61 |
| CHEMBL428734 | PYRIDOXAL BENZOYL HYDRAZONE | IC50 | = | 31820.0 | nM | 4.50 |
| CHEMBL238480 | PYRIDOXAL THIOBENZOYL HYDRAZONE | IC50 | = | 58250.0 | nM | 4.24 |