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Assay Detail

CHEMBL901773

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of human NCI-H460 cells after 4 days by MTT assay
ChEMBL ↗
58
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NCI-H460
Confidence 1 — Organism
Curated By Autocuration

Target

NCI-H460 (CHEMBL396) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Activity of sulfonium bisphosphonates on tumor cell lines.
Zhang Y, Hudock MP, Krysiak K, Cao R, Bergan K, Yin F, Leon A, Oldfield E.
J Med Chem (2007) 50 : 6067 -6079
PubMed 17963374 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 58 5.05 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL238046 — — 2 6.70
CHEMBL237589 — — 2 6.50
CHEMBL237808 — — 2 6.32
CHEMBL237379 — — 2 5.94
CHEMBL398105 — — 2 5.91
CHEMBL235481 — — 2 5.90
CHEMBL440978 — — 1 5.47
CHEMBL237378 — — 1 5.43
CHEMBL235690 — — 2 4.91
CHEMBL236746 — — 2 4.90
CHEMBL236977 — — 2 4.80
CHEMBL235307 — — 2 4.63
CHEMBL393854 — — 2 4.60
CHEMBL235537 — — 2 4.32
CHEMBL277582 — — 2 4.30
CHEMBL237203 — — 2 4.20
CHEMBL235052 — — 2 4.13
CHEMBL393054 — — 2 4.10
CHEMBL392675 — — 1 4.02
CHEMBL235059 — — 2 4.02
CHEMBL238045 — — 1 -
CHEMBL392884 — — 1 -
CHEMBL237240 — — 1 -
CHEMBL437563 — — 1 -
CHEMBL236542 — — 1 -
CHEMBL236580 — — 2 -
CHEMBL236123 — — 2 -
CHEMBL391397 — — 2 -
CHEMBL392883 — — 2 -
CHEMBL394677 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL238046 — IC50 = 199.53 nM 6.70
CHEMBL238046 — IC50 = 210.0 nM 6.68
CHEMBL237589 — IC50 = 320.0 nM 6.50
CHEMBL237589 — IC50 = 316.23 nM 6.50
CHEMBL237808 — IC50 = 480.0 nM 6.32
CHEMBL237808 — IC50 = 501.19 nM 6.30
CHEMBL237379 — IC50 = 1150.0 nM 5.94
CHEMBL398105 — IC50 = 1230.0 nM 5.91
CHEMBL237379 — IC50 = 1258.93 nM 5.90
CHEMBL398105 — IC50 = 1258.93 nM 5.90
CHEMBL235481 — IC50 = 1258.93 nM 5.90
CHEMBL235481 — IC50 = 1410.0 nM 5.85
CHEMBL440978 — IC50 = 3400.0 nM 5.47
CHEMBL237378 — IC50 = 3700.0 nM 5.43
CHEMBL235690 — IC50 = 12300.0 nM 4.91
CHEMBL235690 — IC50 = 12589.25 nM 4.90
CHEMBL236746 — IC50 = 12589.25 nM 4.90
CHEMBL236746 — IC50 = 13800.0 nM 4.86
CHEMBL236977 — IC50 = 15848.93 nM 4.80
CHEMBL236977 — IC50 = 16600.0 nM 4.78
CHEMBL235307 — IC50 = 23440.0 nM 4.63
CHEMBL393854 — IC50 = 25118.86 nM 4.60
CHEMBL235307 — IC50 = 25118.86 nM 4.60
CHEMBL393854 — IC50 = 25700.0 nM 4.59
CHEMBL235537 — IC50 = 47860.0 nM 4.32
CHEMBL235537 — IC50 = 50118.72 nM 4.30
CHEMBL277582 — IC50 = 50118.72 nM 4.30
CHEMBL277582 — IC50 = 54950.0 nM 4.26
CHEMBL237203 — IC50 = 63095.73 nM 4.20
CHEMBL237203 — IC50 = 66070.0 nM 4.18
CHEMBL235052 — IC50 = 74130.0 nM 4.13
CHEMBL235052 — IC50 = 79432.82 nM 4.10
CHEMBL393054 — IC50 = 79432.82 nM 4.10
CHEMBL393054 — IC50 = 83180.0 nM 4.08
CHEMBL235059 — IC50 = 95500.0 nM 4.02
CHEMBL392675 — IC50 = 95100.0 nM 4.02
CHEMBL235059 — IC50 = 100000.0 nM 4.00
CHEMBL391397 — IC50 = 208930.0 nM -
CHEMBL236123 — IC50 = 158490.0 nM -
CHEMBL236123 — IC50 = 158489.32 nM -
CHEMBL236580 — IC50 = 125890.0 nM -
CHEMBL238045 — IC50 = 183000.0 nM -
CHEMBL235062 — IC50 = 758580.0 nM -
CHEMBL235062 — IC50 = 794328.23 nM -
CHEMBL392884 — IC50 = 128000.0 nM -
CHEMBL237240 — IC50 = 151000.0 nM -
CHEMBL437563 — IC50 > 400000000.0 nM -
CHEMBL236542 — IC50 > 400000000.0 nM -
CHEMBL391397 — IC50 = 199526.23 nM -
CHEMBL236580 — IC50 = 125892.54 nM -