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Assay Detail

CHEMBL901774

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of human MCF7 cells after 4 days by MTT assay
ChEMBL ↗
58
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Activity of sulfonium bisphosphonates on tumor cell lines.
Zhang Y, Hudock MP, Krysiak K, Cao R, Bergan K, Yin F, Leon A, Oldfield E.
J Med Chem (2007) 50 : 6067 -6079
PubMed 17963374 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 58 4.97 6.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL238046 — — 2 6.62
CHEMBL237589 — — 2 6.21
CHEMBL237379 — — 2 6.02
CHEMBL235481 — — 2 6.00
CHEMBL398105 — — 2 5.90
CHEMBL440978 — — 1 5.55
CHEMBL237808 — — 2 5.00
CHEMBL237378 — — 1 4.85
CHEMBL236746 — — 2 4.80
CHEMBL235690 — — 2 4.70
CHEMBL235307 — — 2 4.70
CHEMBL393854 — — 2 4.50
CHEMBL235537 — — 2 4.34
CHEMBL277582 — — 2 4.24
CHEMBL236977 — — 2 4.03
CHEMBL393054 — — 2 4.02
CHEMBL237203 — — 2 4.00
CHEMBL236580 — — 2 4.00
CHEMBL392884 — — 1 -
CHEMBL392675 — — 1 -
CHEMBL238045 — — 1 -
CHEMBL237240 — — 1 -
CHEMBL236123 — — 2 -
CHEMBL391397 — — 2 -
CHEMBL392883 — — 2 -
CHEMBL236542 — — 1 -
CHEMBL437563 — — 1 -
CHEMBL394677 — — 2 -
CHEMBL235052 — — 2 -
CHEMBL235059 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL238046 — IC50 = 240.0 nM 6.62
CHEMBL238046 — IC50 = 251.19 nM 6.60
CHEMBL237589 — IC50 = 620.0 nM 6.21
CHEMBL237589 — IC50 = 630.96 nM 6.20
CHEMBL237379 — IC50 = 950.0 nM 6.02
CHEMBL237379 — IC50 = 1000.0 nM 6.00
CHEMBL235481 — IC50 = 1000.0 nM 6.00
CHEMBL235481 — IC50 = 1120.0 nM 5.95
CHEMBL398105 — IC50 = 1258.93 nM 5.90
CHEMBL398105 — IC50 = 1410.0 nM 5.85
CHEMBL440978 — IC50 = 2800.0 nM 5.55
CHEMBL237808 — IC50 = 10000.0 nM 5.00
CHEMBL237808 — IC50 = 10960.0 nM 4.96
CHEMBL237378 — IC50 = 14200.0 nM 4.85
CHEMBL236746 — IC50 = 15848.93 nM 4.80
CHEMBL236746 — IC50 = 17780.0 nM 4.75
CHEMBL235690 — IC50 = 19952.62 nM 4.70
CHEMBL235307 — IC50 = 19952.62 nM 4.70
CHEMBL235690 — IC50 = 21380.0 nM 4.67
CHEMBL235307 — IC50 = 21380.0 nM 4.67
CHEMBL393854 — IC50 = 31622.78 nM 4.50
CHEMBL393854 — IC50 = 32360.0 nM 4.49
CHEMBL235537 — IC50 = 45710.0 nM 4.34
CHEMBL235537 — IC50 = 50118.72 nM 4.30
CHEMBL277582 — IC50 = 57540.0 nM 4.24
CHEMBL277582 — IC50 = 63095.73 nM 4.20
CHEMBL236977 — IC50 = 93330.0 nM 4.03
CHEMBL393054 — IC50 = 95500.0 nM 4.02
CHEMBL393054 — IC50 = 100000.0 nM 4.00
CHEMBL236580 — IC50 = 100000.0 nM 4.00
CHEMBL236580 — IC50 = 100000.0 nM 4.00
CHEMBL237203 — IC50 = 100000.0 nM 4.00
CHEMBL236977 — IC50 = 100000.0 nM 4.00
CHEMBL392883 — IC50 = 512860.0 nM -
CHEMBL392883 — IC50 = 501187.23 nM -
CHEMBL391397 — IC50 = 302000.0 nM -
CHEMBL237203 — IC50 = 104710.0 nM -
CHEMBL236123 — IC50 = 194980.0 nM -
CHEMBL236123 — IC50 = 199526.23 nM -
CHEMBL277580 — IC50 = 199526.23 nM -
CHEMBL277580 — IC50 = 199530.0 nM -
CHEMBL235061 — IC50 = 398107.17 nM -
CHEMBL235061 — IC50 = 389050.0 nM -
CHEMBL237240 — IC50 = 184000.0 nM -
CHEMBL392884 — IC50 = 224000.0 nM -
CHEMBL392675 — IC50 = 258000.0 nM -
CHEMBL235062 — IC50 = 794328.23 nM -
CHEMBL235062 — IC50 = 812830.0 nM -
CHEMBL238045 — IC50 = 251000.0 nM -
CHEMBL391397 — IC50 = 316227.77 nM -