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Assay Detail

CHEMBL901775

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of human SF268 cells after 4 days by MTT assay
ChEMBL ↗
58
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SF-268
Confidence 1 — Organism
Curated By Intermediate

Target

SF-268 (CHEMBL613977) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Activity of sulfonium bisphosphonates on tumor cell lines.
Zhang Y, Hudock MP, Krysiak K, Cao R, Bergan K, Yin F, Leon A, Oldfield E.
J Med Chem (2007) 50 : 6067 -6079
PubMed 17963374 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 58 5.04 6.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL238046 — — 2 6.54
CHEMBL237589 — — 2 6.43
CHEMBL237808 — — 2 6.10
CHEMBL235481 — — 2 6.00
CHEMBL237379 — — 2 5.83
CHEMBL398105 — — 2 5.80
CHEMBL440978 — — 1 5.51
CHEMBL237378 — — 1 5.43
CHEMBL236746 — — 2 5.00
CHEMBL235690 — — 2 4.83
CHEMBL235307 — — 2 4.80
CHEMBL393854 — — 2 4.70
CHEMBL236977 — — 2 4.50
CHEMBL235537 — — 2 4.40
CHEMBL277582 — — 2 4.31
CHEMBL237203 — — 2 4.20
CHEMBL393054 — — 2 4.10
CHEMBL235052 — — 2 4.02
CHEMBL392675 — — 1 4.00
CHEMBL236580 — — 2 4.00
CHEMBL437563 — — 1 -
CHEMBL238045 — — 1 -
CHEMBL236542 — — 1 -
CHEMBL392884 — — 1 -
CHEMBL237240 — — 1 -
CHEMBL236123 — — 2 -
CHEMBL391397 — — 2 -
CHEMBL392883 — — 2 -
CHEMBL394677 — — 2 -
CHEMBL235059 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL238046 — IC50 = 290.0 nM 6.54
CHEMBL238046 — IC50 = 316.23 nM 6.50
CHEMBL237589 — IC50 = 370.0 nM 6.43
CHEMBL237589 — IC50 = 398.11 nM 6.40
CHEMBL237808 — IC50 = 794.33 nM 6.10
CHEMBL237808 — IC50 = 880.0 nM 6.06
CHEMBL235481 — IC50 = 1000.0 nM 6.00
CHEMBL235481 — IC50 = 1080.0 nM 5.97
CHEMBL237379 — IC50 = 1490.0 nM 5.83
CHEMBL398105 — IC50 = 1584.89 nM 5.80
CHEMBL237379 — IC50 = 1584.89 nM 5.80
CHEMBL398105 — IC50 = 1710.0 nM 5.77
CHEMBL440978 — IC50 = 3100.0 nM 5.51
CHEMBL237378 — IC50 = 3700.0 nM 5.43
CHEMBL236746 — IC50 = 10000.0 nM 5.00
CHEMBL236746 — IC50 = 10700.0 nM 4.97
CHEMBL235690 — IC50 = 14700.0 nM 4.83
CHEMBL235307 — IC50 = 15848.93 nM 4.80
CHEMBL235690 — IC50 = 15848.93 nM 4.80
CHEMBL235307 — IC50 = 17900.0 nM 4.75
CHEMBL393854 — IC50 = 19952.62 nM 4.70
CHEMBL393854 — IC50 = 20300.0 nM 4.69
CHEMBL236977 — IC50 = 31622.78 nM 4.50
CHEMBL236977 — IC50 = 34500.0 nM 4.46
CHEMBL235537 — IC50 = 39810.72 nM 4.40
CHEMBL235537 — IC50 = 43900.0 nM 4.36
CHEMBL277582 — IC50 = 48600.0 nM 4.31
CHEMBL277582 — IC50 = 50118.72 nM 4.30
CHEMBL237203 — IC50 = 63095.73 nM 4.20
CHEMBL237203 — IC50 = 65900.0 nM 4.18
CHEMBL393054 — IC50 = 79432.82 nM 4.10
CHEMBL393054 — IC50 = 87800.0 nM 4.06
CHEMBL235052 — IC50 = 96100.0 nM 4.02
CHEMBL235052 — IC50 = 100000.0 nM 4.00
CHEMBL236580 — IC50 = 100000.0 nM 4.00
CHEMBL392675 — IC50 = 100000.0 nM 4.00
CHEMBL236123 — IC50 = 129000.0 nM -
CHEMBL391397 — IC50 = 251188.64 nM -
CHEMBL392883 — IC50 = 398107.17 nM -
CHEMBL394677 — IC50 = 251188.64 nM -
CHEMBL235059 — IC50 = 199526.23 nM -
CHEMBL277580 — IC50 = 158489.32 nM -
CHEMBL235061 — IC50 = 199526.23 nM -
CHEMBL235062 — IC50 = 630957.34 nM -
CHEMBL236580 — IC50 = 101000.0 nM -
CHEMBL235059 — IC50 = 223000.0 nM -
CHEMBL277580 — IC50 = 171000.0 nM -
CHEMBL394677 — IC50 = 264000.0 nM -
CHEMBL235061 — IC50 = 196000.0 nM -
CHEMBL235062 — IC50 = 714000.0 nM -