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Assay Detail

CHEMBL901776

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human FPPS
22
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Farnesyl pyrophosphate synthase (CHEMBL1782)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Activity of sulfonium bisphosphonates on tumor cell lines.
Zhang Y, Hudock MP, Krysiak K, Cao R, Bergan K, Yin F, Leon A, Oldfield E.
J Med Chem (2007) 50 : 6067 -6079
PubMed 17963374 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 5.73 6.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL237589 2 6.62
CHEMBL238046 2 6.60
CHEMBL237379 2 6.60
CHEMBL235690 2 6.44
CHEMBL235059 2 6.30
CHEMBL392884 2 6.00
CHEMBL277580 2 6.00
CHEMBL398105 2 5.13
CHEMBL237808 2 5.10
CHEMBL392675 2 5.05
CHEMBL235481 2 4.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL237589 IC50 = 240.0 nM 6.62
CHEMBL237589 IC50 = 251.19 nM 6.60
CHEMBL238046 IC50 = 251.19 nM 6.60
CHEMBL237379 IC50 = 251.19 nM 6.60
CHEMBL238046 IC50 = 260.0 nM 6.58
CHEMBL235690 IC50 = 360.0 nM 6.44
CHEMBL235690 IC50 = 398.11 nM 6.40
CHEMBL235059 IC50 = 501.19 nM 6.30
CHEMBL235059 IC50 = 530.0 nM 6.28
CHEMBL277580 IC50 = 1000.0 nM 6.00
CHEMBL392884 IC50 = 1000.0 nM 6.00
CHEMBL277580 IC50 = 1030.0 nM 5.99
CHEMBL392884 IC50 = 1080.0 nM 5.97
CHEMBL398105 IC50 = 7450.0 nM 5.13
CHEMBL237808 IC50 = 7943.28 nM 5.10
CHEMBL398105 IC50 = 7943.28 nM 5.10
CHEMBL237808 IC50 = 8470.0 nM 5.07
CHEMBL392675 IC50 = 9000.0 nM 5.05
CHEMBL392675 IC50 = 10000.0 nM 5.00
CHEMBL237379 IC50 = 27400.0 nM 4.56
CHEMBL235481 IC50 = 45600.0 nM 4.34
CHEMBL235481 IC50 = 50118.72 nM 4.30